Blocking Caspase-2 (the liver’s guardian enzyme) to treat fatty liver may produce chronic damage and multiply the risk of ...

New research has shown that inhibiting caspase-2 to treat fatty liver disease may increase inflammation, fibrosis and cancer ...

Most unnecessary or dangerous cells such as virus-infected cells commit suicide by activating an in-built suicide program. This type of cell death is referred to as "programmed cell death". Until ...

Researchers have discovered using mice and human clinical specimens that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive ...

Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead ...

Scientists have discovered that blocking a key cellular enzyme thought to protect against fatty liver disease may instead increase the risk of chronic liver damage and cancer as we age. In a major new ...

Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Researchers recognize CASP4/11 as ...