Myelodysplastic syndromes (MDS) are malignant disorders arising from hematopoietic stem cells, yet the precise epigenetic abnormalities occurring in the primitive stem cells remain poorly understood.

Published on April 01, 2026, in Volume 2, article number 19 of the journal Immunity & Inflammation, a collaborative team led ...

CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA. DNA methylation is a process in which a methyl group is ...

DNA methylation is an epigenetic modification crucial to normal development, with its dysregulation leading to various diseases including cancer. As interest in epigenomics grows, an innovative ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics-meticulously placed chemical tags that influence which genes are expressed in ...

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

Researchers have developed the first comprehensive atlas of allele-specific DNA methylation across 39 human cell types, revealing a complex landscape of epigenetic regulation. The study identified ...

"We find that epigenetic clocks based on the entropy of methylation states predict chronological age with similar accuracy as common approaches that are based on methylation levels of individual ...