A hallmark of cancerous cells is an abnormal number of chromosomes or chromosome arms, known as aneuploidy. While aneuploidy is detrimental to regular cells, it occurs in as many as 90% of tumors. How ...

A study shows that extra chromosomes in fetal cells create pre-leukemic clones that can persist for years, requiring later triggers to develop into leukemia, revealing a two-stage disease model.

"Inter-chromosome connections may prove to be an integral and pervasive governing feature of chromosome organization in many types of human cells," says Stowers Investigator Jennifer Gerton, Ph.D., ...

B-cell acute lymphoblastic leukemia is the most common form of childhood cancer. In this type of cancer, which affects blood cells, one of the most common abnormalities is the presence of cells with ...